Adam Radwan, Jamie George, Jonny May, Maro Itoje and Ben Youngs have all scored trys for England.
The Lions are playing without captain Owen Farrell who tested positive for Covid on Friday.
Following Farrell’s absence, George Furbank started at fly-half and Courtney Lawes is leading the team.
Gloucester's Mark Atkinson is also in line to make his debut during the game.